The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

Hsp90 is required for the folding, stability and activity of several drivers of oncogenesis. Here the authors show that Folliculin-interacting proteins (FNIP) 1 and 2, whose expression correlates with the cellular response to Hsp90 inhibitors, are co-chaperones of Hsp90 that function by inhibiting i...

Full description

Saved in:
Bibliographic Details
Main Authors: Mark R. Woodford, Diana M. Dunn, Adam R. Blanden, Dante Capriotti, David Loiselle, Chrisostomos Prodromou, Barry Panaretou, Philip F. Hughes, Aaron Smith, Wendi Ackerman, Timothy A. Haystead, Stewart N. Loh, Dimitra Bourboulia, Laura S. Schmidt, W. Marston Linehan, Gennady Bratslavsky, Mehdi Mollapour
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/51f03ab61e4442f99c334fc8fe1d2ccd
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/51f03ab61e4442f99c334fc8fe1d2ccd

Similar Items