Immune Synapse Residency of Orai1 Alters Ca<sup>2+</sup> Response of T Cells
CRAC, which plays important role in Ca<sup>2+</sup>-dependent T-lymphocyte activation, is composed of the ER-resident STIM1 and the plasma membrane Orai1 pore-forming subunit. Both accumulate at the immunological synapse (IS) between a T cell and an antigen-presenting cell (APC). We hypo...
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Formato: | article |
Lenguaje: | EN |
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MDPI AG
2021
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Acceso en línea: | https://doaj.org/article/524ec433210a453aa979554d90566f7e |
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