The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase

The NDM-1 metallo-β-lactamase confers resistance to β-lactam antibiotics. Here, the authors show that the antimicrobial peptide thanatin is active against NDM-1-producing bacteria through a dual mechanism of action consisting of disruption of outer membrane integrity and inhibition of the NDM-1 enzy...

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Autores principales: Bo Ma, Chao Fang, Linshan Lu, Mingzhi Wang, Xiaoyan Xue, Ying Zhou, Mingkai Li, Yue Hu, Xiaoxing Luo, Zheng Hou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/5264630a22df4ed9ae5b7ee92c052341
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