Expression of Human Mutant Preproinsulins Induced Unfolded Protein Response, <i>Gadd45</i> Expression, JAK-STAT Activation, and Growth Inhibition in <i>Drosophila</i>
Mutations in the insulin gene (INS) are frequently associated with human permanent neonatal diabetes mellitus. However, the mechanisms underlying the onset of this genetic disease is not sufficiently decoded. We induced expression of two types of human mutant INSs in <i>Drosophila</i> us...
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| Main Authors: | , , , |
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| Format: | article |
| Language: | EN |
| Published: |
MDPI AG
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/526e22f66d1c40a28195b49a6c45a81f |
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