A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons. Mislocalization of TAR DNA-binding protein 43 (TDP-43) is an early event in the formation of cytoplasmic TDP-43-positive inclusions in motor neurons and a hallmark of ALS. Howeve...

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Detalles Bibliográficos
Autores principales: Yu-Ju Liu, Hung-Chih Kuo, Yijuang Chern
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
ALS
S6
Acceso en línea:https://doaj.org/article/52a7d3f8cf4a4ab29473f8dcf59123f4
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