Development of antipsychotic medications with novel mechanisms of action based on computational modeling of hippocampal neuropathology.

A large number of cellular level abnormalities have been identified in the hippocampus of schizophrenic subjects. Nonetheless, it remains uncertain how these pathologies interact at a system level to create clinical symptoms, and this has hindered the development of more effective antipsychotic medi...

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Autores principales: Peter J Siekmeier, David P vanMaanen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/52b38aab149b40a3bbc80148cfde341a
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