Activation mechanism of human soluble guanylate cyclase by stimulators and activators

Soluble guanylate cyclase (sGC) is a validated drug target for cardiovascular diseases. Here, the authors report structures of human sGC in complex with NO and sGC stimulators or activator, providing insight into the mechanism of sGC activation by pharmacological compounds.

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Autores principales: Rui Liu, Yunlu Kang, Lei Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/52e3ea2fe9834548a8209df389102dd7
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