Activation mechanism of human soluble guanylate cyclase by stimulators and activators

Soluble guanylate cyclase (sGC) is a validated drug target for cardiovascular diseases. Here, the authors report structures of human sGC in complex with NO and sGC stimulators or activator, providing insight into the mechanism of sGC activation by pharmacological compounds.

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Detalles Bibliográficos
Autores principales:	Rui Liu, Yunlu Kang, Lei Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/52e3ea2fe9834548a8209df389102dd7
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spelling	oai:doaj.org-article:52e3ea2fe9834548a8209df389102dd72021-12-02T18:49:54ZActivation mechanism of human soluble guanylate cyclase by stimulators and activators10.1038/s41467-021-25617-02041-1723https://doaj.org/article/52e3ea2fe9834548a8209df389102dd72021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25617-0https://doaj.org/toc/2041-1723Soluble guanylate cyclase (sGC) is a validated drug target for cardiovascular diseases. Here, the authors report structures of human sGC in complex with NO and sGC stimulators or activator, providing insight into the mechanism of sGC activation by pharmacological compounds.Rui LiuYunlu KangLei ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rui Liu Yunlu Kang Lei Chen Activation mechanism of human soluble guanylate cyclase by stimulators and activators
description	Soluble guanylate cyclase (sGC) is a validated drug target for cardiovascular diseases. Here, the authors report structures of human sGC in complex with NO and sGC stimulators or activator, providing insight into the mechanism of sGC activation by pharmacological compounds.
format	article
author	Rui Liu Yunlu Kang Lei Chen
author_facet	Rui Liu Yunlu Kang Lei Chen
author_sort	Rui Liu
title	Activation mechanism of human soluble guanylate cyclase by stimulators and activators
title_short	Activation mechanism of human soluble guanylate cyclase by stimulators and activators
title_full	Activation mechanism of human soluble guanylate cyclase by stimulators and activators
title_fullStr	Activation mechanism of human soluble guanylate cyclase by stimulators and activators
title_full_unstemmed	Activation mechanism of human soluble guanylate cyclase by stimulators and activators
title_sort	activation mechanism of human soluble guanylate cyclase by stimulators and activators
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/52e3ea2fe9834548a8209df389102dd7
work_keys_str_mv	AT ruiliu activationmechanismofhumansolubleguanylatecyclasebystimulatorsandactivators AT yunlukang activationmechanismofhumansolubleguanylatecyclasebystimulatorsandactivators AT leichen activationmechanismofhumansolubleguanylatecyclasebystimulatorsandactivators
_version_	1718377502981750784

Activation mechanism of human soluble guanylate cyclase by stimulators and activators

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