Structural basis for the inhibition of translation through eIF2α phosphorylation

During stress, protein synthesis is inhibited through phosphorylation of the initiation factor eIF2 on its alpha subunit and its interaction with eIF2B. Here the authors describe a structure of the yeast eIF2B in complex with its substrate - the GDP-bound phosphorylated eIF2, providing insights into...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Yuliya Gordiyenko, José Luis Llácer, V. Ramakrishnan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/52efb5f0de1c46dfac0703373fffc48f
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!