Structural basis for the inhibition of translation through eIF2α phosphorylation

During stress, protein synthesis is inhibited through phosphorylation of the initiation factor eIF2 on its alpha subunit and its interaction with eIF2B. Here the authors describe a structure of the yeast eIF2B in complex with its substrate - the GDP-bound phosphorylated eIF2, providing insights into...

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Autores principales:	Yuliya Gordiyenko, José Luis Llácer, V. Ramakrishnan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/52efb5f0de1c46dfac0703373fffc48f
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spelling	oai:doaj.org-article:52efb5f0de1c46dfac0703373fffc48f2021-12-02T17:01:26ZStructural basis for the inhibition of translation through eIF2α phosphorylation10.1038/s41467-019-10606-12041-1723https://doaj.org/article/52efb5f0de1c46dfac0703373fffc48f2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10606-1https://doaj.org/toc/2041-1723During stress, protein synthesis is inhibited through phosphorylation of the initiation factor eIF2 on its alpha subunit and its interaction with eIF2B. Here the authors describe a structure of the yeast eIF2B in complex with its substrate - the GDP-bound phosphorylated eIF2, providing insights into how phosphorylation results in a tighter interaction with eIF2B.Yuliya GordiyenkoJosé Luis LlácerV. RamakrishnanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuliya Gordiyenko José Luis Llácer V. Ramakrishnan Structural basis for the inhibition of translation through eIF2α phosphorylation
description	During stress, protein synthesis is inhibited through phosphorylation of the initiation factor eIF2 on its alpha subunit and its interaction with eIF2B. Here the authors describe a structure of the yeast eIF2B in complex with its substrate - the GDP-bound phosphorylated eIF2, providing insights into how phosphorylation results in a tighter interaction with eIF2B.
format	article
author	Yuliya Gordiyenko José Luis Llácer V. Ramakrishnan
author_facet	Yuliya Gordiyenko José Luis Llácer V. Ramakrishnan
author_sort	Yuliya Gordiyenko
title	Structural basis for the inhibition of translation through eIF2α phosphorylation
title_short	Structural basis for the inhibition of translation through eIF2α phosphorylation
title_full	Structural basis for the inhibition of translation through eIF2α phosphorylation
title_fullStr	Structural basis for the inhibition of translation through eIF2α phosphorylation
title_full_unstemmed	Structural basis for the inhibition of translation through eIF2α phosphorylation
title_sort	structural basis for the inhibition of translation through eif2α phosphorylation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/52efb5f0de1c46dfac0703373fffc48f
work_keys_str_mv	AT yuliyagordiyenko structuralbasisfortheinhibitionoftranslationthrougheif2aphosphorylation AT joseluisllacer structuralbasisfortheinhibitionoftranslationthrougheif2aphosphorylation AT vramakrishnan structuralbasisfortheinhibitionoftranslationthrougheif2aphosphorylation
_version_	1718382147123806208

Structural basis for the inhibition of translation through eIF2α phosphorylation

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