Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
The latent HIV-1 reservoir is the key obstacle for curing HIV-1 infection, but the timepoint at which the HIV-1 reservoir is established is currently unclear. Here, Whitney et al. show in non-human primates that the SIV reservoir in CD4+ T cells is seeded within the first 2 days after infection.
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Main Authors: | James B. Whitney, So-Yon Lim, Christa E. Osuna, Jessica L. Kublin, Elsa Chen, Gyeol Yoon, Po-Ting Liu, Peter Abbink, Erica N. Borducci, Alison Hill, Mark G. Lewis, Romas Geleziunas, Merlin L. Robb, Nelson L. Michael, Dan H. Barouch |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2018
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Online Access: | https://doaj.org/article/52f46cb5b9da47d5be04a0ba3ac32ed1 |
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