Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC

Aberrant telomerase reverse transcriptase (TERT) expression is crucial for tumor survival and cancer cells escaping apoptosis. Multiple TERT-locus variants at 5p15 have been discovered in association with cancer risk, yet the underlying mechanisms and clinical impacts remain unclear. Here, our assoc...

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Autores principales: Xiaoming Dong, Qin Zhang, Jinglan Hao, Qianwen Xie, Binbing Xu, Peng Zhang, Haicheng Lu, Qilai Huang, Tielin Yang, Gong-Hong Wei, Rong Na, Ping Gao
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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MYC
Acceso en línea:https://doaj.org/article/53103bcead54426d874775057ac00f58
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