An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism
The signalling pathways underpinning cell growth and invasion use overlapping components, yet how mutually exclusive responses occur is unclear. Here, the authors show that alternate isoforms of the ARF GTPase exchange factor IQSEC1 direct phosphoinositide metabolism to control this switch.
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Nature Portfolio
2021
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oai:doaj.org-article:5313ed90f36c4817a2437ea2428b588c2021-12-02T13:15:56ZAn ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism10.1038/s41467-021-21847-42041-1723https://doaj.org/article/5313ed90f36c4817a2437ea2428b588c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21847-4https://doaj.org/toc/2041-1723The signalling pathways underpinning cell growth and invasion use overlapping components, yet how mutually exclusive responses occur is unclear. Here, the authors show that alternate isoforms of the ARF GTPase exchange factor IQSEC1 direct phosphoinositide metabolism to control this switch.Marisa NackeEmma SandilandsKonstantina NikolatouÁlvaro Román-FernándezSusan MasonRachana PatelSergio LillaTamas YellandLaura C. A. GalbraithEva C. FreckmannLynn McGarryJennifer P. MortonEmma ShanksHing Y. LeungElke MarkertShehab IsmailSara ZanivanKaren BlythDavid M. BryantNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Marisa Nacke Emma Sandilands Konstantina Nikolatou Álvaro Román-Fernández Susan Mason Rachana Patel Sergio Lilla Tamas Yelland Laura C. A. Galbraith Eva C. Freckmann Lynn McGarry Jennifer P. Morton Emma Shanks Hing Y. Leung Elke Markert Shehab Ismail Sara Zanivan Karen Blyth David M. Bryant An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism |
| description |
The signalling pathways underpinning cell growth and invasion use overlapping components, yet how mutually exclusive responses occur is unclear. Here, the authors show that alternate isoforms of the ARF GTPase exchange factor IQSEC1 direct phosphoinositide metabolism to control this switch. |
| format |
article |
| author |
Marisa Nacke Emma Sandilands Konstantina Nikolatou Álvaro Román-Fernández Susan Mason Rachana Patel Sergio Lilla Tamas Yelland Laura C. A. Galbraith Eva C. Freckmann Lynn McGarry Jennifer P. Morton Emma Shanks Hing Y. Leung Elke Markert Shehab Ismail Sara Zanivan Karen Blyth David M. Bryant |
| author_facet |
Marisa Nacke Emma Sandilands Konstantina Nikolatou Álvaro Román-Fernández Susan Mason Rachana Patel Sergio Lilla Tamas Yelland Laura C. A. Galbraith Eva C. Freckmann Lynn McGarry Jennifer P. Morton Emma Shanks Hing Y. Leung Elke Markert Shehab Ismail Sara Zanivan Karen Blyth David M. Bryant |
| author_sort |
Marisa Nacke |
| title |
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism |
| title_short |
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism |
| title_full |
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism |
| title_fullStr |
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism |
| title_full_unstemmed |
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism |
| title_sort |
arf gtpase module promoting invasion and metastasis through regulating phosphoinositide metabolism |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5313ed90f36c4817a2437ea2428b588c |
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