PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity

por Eyad Kalawy Fansa, Stefanie Kristine Kösling, Eldar Zent, Alfred Wittinghofer, Shehab Ismail
Publicado 2016

Identification of pyrazolopyridazinones as PDEδ inhibitors

por Björn Papke, Sandip Murarka, Holger A Vogel, Pablo Martín-Gago, Marija Kovacevic, Dina C Truxius, Eyad K Fansa, Shehab Ismail, Gunther Zimmermann, Kaatje Heinelt, Carsten Schultz-Fademrecht, Alaa Al Saabi, Matthias Baumann, Peter Nussbaumer, Alfred Wittinghofer, Herbert Waldmann, Philippe I.H. Bastiaens
Publicado 2016

An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism

por Marisa Nacke, Emma Sandilands, Konstantina Nikolatou, Álvaro Román-Fernández, Susan Mason, Rachana Patel, Sergio Lilla, Tamas Yelland, Laura C. A. Galbraith, Eva C. Freckmann, Lynn McGarry, Jennifer P. Morton, Emma Shanks, Hing Y. Leung, Elke Markert, Shehab Ismail, Sara Zanivan, Karen Blyth, David M. Bryant
Publicado 2021

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity

por Juan R. Hernandez-Fernaud, Elena Ruengeler, Andrea Casazza, Lisa J. Neilson, Ellie Pulleine, Alice Santi, Shehab Ismail, Sergio Lilla, Sandeep Dhayade, Iain R. MacPherson, Iain McNeish, Darren Ennis, Hala Ali, Fernanda G. Kugeratski, Heba Al Khamici, Maartje van den Biggelaar, Peter V.E. van den Berghe, Catherine Cloix, Laura McDonald, David Millan, Aoisha Hoyle, Anna Kuchnio, Peter Carmeliet, Stella M. Valenzuela, Karen Blyth, Huabing Yin, Massimiliano Mazzone, Jim C. Norman, Sara Zanivan
Publicado 2017