Rational design and characterization of D-Phe-Pro-D-Arg-derived direct thrombin inhibitors.

The tremendous social and economic impact of thrombotic disorders, together with the considerable risks associated to the currently available therapies, prompt for the development of more efficient and safer anticoagulants. Novel peptide-based thrombin inhibitors were identified using in silico stru...

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Autores principales: Ana C Figueiredo, Cristina C Clement, Sheuli Zakia, Julian Gingold, Manfred Philipp, Pedro J B Pereira
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/53417410e5c14099ab350aae53f0c083
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