ATP-dependent hydroxylation of an unactivated primary carbon with water

Monooxygenases catalyse the hydroxylation of C-H bonds using oxygen as a co-substrate, which, in turn, is unavailable for anaerobic bacteria. Here, the authors report a three-step reaction cascade involving two hydroxylases and one dehydratase which hydroxylate the C26 methyl group of cholesterol wi...

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Autores principales: Christian Jacoby, Sascha Ferlaino, Dominik Bezold, Henning Jessen, Michael Müller, Matthias Boll
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/535dccae5c7b42d891408b93dd8fd29d
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