ATP-dependent hydroxylation of an unactivated primary carbon with water

Monooxygenases catalyse the hydroxylation of C-H bonds using oxygen as a co-substrate, which, in turn, is unavailable for anaerobic bacteria. Here, the authors report a three-step reaction cascade involving two hydroxylases and one dehydratase which hydroxylate the C26 methyl group of cholesterol wi...

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Autores principales:	Christian Jacoby, Sascha Ferlaino, Dominik Bezold, Henning Jessen, Michael Müller, Matthias Boll
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/535dccae5c7b42d891408b93dd8fd29d
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spelling	oai:doaj.org-article:535dccae5c7b42d891408b93dd8fd29d2021-12-02T14:53:37ZATP-dependent hydroxylation of an unactivated primary carbon with water10.1038/s41467-020-17675-72041-1723https://doaj.org/article/535dccae5c7b42d891408b93dd8fd29d2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17675-7https://doaj.org/toc/2041-1723Monooxygenases catalyse the hydroxylation of C-H bonds using oxygen as a co-substrate, which, in turn, is unavailable for anaerobic bacteria. Here, the authors report a three-step reaction cascade involving two hydroxylases and one dehydratase which hydroxylate the C26 methyl group of cholesterol with water as a co-substrate.Christian JacobySascha FerlainoDominik BezoldHenning JessenMichael MüllerMatthias BollNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christian Jacoby Sascha Ferlaino Dominik Bezold Henning Jessen Michael Müller Matthias Boll ATP-dependent hydroxylation of an unactivated primary carbon with water
description	Monooxygenases catalyse the hydroxylation of C-H bonds using oxygen as a co-substrate, which, in turn, is unavailable for anaerobic bacteria. Here, the authors report a three-step reaction cascade involving two hydroxylases and one dehydratase which hydroxylate the C26 methyl group of cholesterol with water as a co-substrate.
format	article
author	Christian Jacoby Sascha Ferlaino Dominik Bezold Henning Jessen Michael Müller Matthias Boll
author_facet	Christian Jacoby Sascha Ferlaino Dominik Bezold Henning Jessen Michael Müller Matthias Boll
author_sort	Christian Jacoby
title	ATP-dependent hydroxylation of an unactivated primary carbon with water
title_short	ATP-dependent hydroxylation of an unactivated primary carbon with water
title_full	ATP-dependent hydroxylation of an unactivated primary carbon with water
title_fullStr	ATP-dependent hydroxylation of an unactivated primary carbon with water
title_full_unstemmed	ATP-dependent hydroxylation of an unactivated primary carbon with water
title_sort	atp-dependent hydroxylation of an unactivated primary carbon with water
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/535dccae5c7b42d891408b93dd8fd29d
work_keys_str_mv	AT christianjacoby atpdependenthydroxylationofanunactivatedprimarycarbonwithwater AT saschaferlaino atpdependenthydroxylationofanunactivatedprimarycarbonwithwater AT dominikbezold atpdependenthydroxylationofanunactivatedprimarycarbonwithwater AT henningjessen atpdependenthydroxylationofanunactivatedprimarycarbonwithwater AT michaelmuller atpdependenthydroxylationofanunactivatedprimarycarbonwithwater AT matthiasboll atpdependenthydroxylationofanunactivatedprimarycarbonwithwater
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ATP-dependent hydroxylation of an unactivated primary carbon with water

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