Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease

Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease

Inflammatory bowel disease is caused by chronic inflammation of the gastrointestinal tract and disturbed immune responses. Here the authors present examination of Cortistatin analogues that display enhanced half-life stability whilst maintaining immunomodulatory functionality.

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Detalles Bibliográficos
Autores principales: Álvaro Rol, Toni Todorovski, Pau Martin-Malpartida, Anna Escolà, Elena Gonzalez-Rey, Eric Aragón, Xavier Verdaguer, Mariona Vallès-Miret, Josep Farrera-Sinfreu, Eduard Puig, Jimena Fernández-Carneado, Berta Ponsati, Mario Delgado, Antoni Riera, Maria J. Macias
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/538094955b874388ace1e053acd30f22
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https://doaj.org/article/538094955b874388ace1e053acd30f22

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