Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease
Inflammatory bowel disease is caused by chronic inflammation of the gastrointestinal tract and disturbed immune responses. Here the authors present examination of Cortistatin analogues that display enhanced half-life stability whilst maintaining immunomodulatory functionality.
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Nature Portfolio
2021
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oai:doaj.org-article:538094955b874388ace1e053acd30f222021-12-02T11:44:50ZStructure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease10.1038/s41467-021-22076-52041-1723https://doaj.org/article/538094955b874388ace1e053acd30f222021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22076-5https://doaj.org/toc/2041-1723Inflammatory bowel disease is caused by chronic inflammation of the gastrointestinal tract and disturbed immune responses. Here the authors present examination of Cortistatin analogues that display enhanced half-life stability whilst maintaining immunomodulatory functionality.Álvaro RolToni TodorovskiPau Martin-MalpartidaAnna EscolàElena Gonzalez-ReyEric AragónXavier VerdaguerMariona Vallès-MiretJosep Farrera-SinfreuEduard PuigJimena Fernández-CarneadoBerta PonsatiMario DelgadoAntoni RieraMaria J. MaciasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Álvaro Rol Toni Todorovski Pau Martin-Malpartida Anna Escolà Elena Gonzalez-Rey Eric Aragón Xavier Verdaguer Mariona Vallès-Miret Josep Farrera-Sinfreu Eduard Puig Jimena Fernández-Carneado Berta Ponsati Mario Delgado Antoni Riera Maria J. Macias Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease |
| description |
Inflammatory bowel disease is caused by chronic inflammation of the gastrointestinal tract and disturbed immune responses. Here the authors present examination of Cortistatin analogues that display enhanced half-life stability whilst maintaining immunomodulatory functionality. |
| format |
article |
| author |
Álvaro Rol Toni Todorovski Pau Martin-Malpartida Anna Escolà Elena Gonzalez-Rey Eric Aragón Xavier Verdaguer Mariona Vallès-Miret Josep Farrera-Sinfreu Eduard Puig Jimena Fernández-Carneado Berta Ponsati Mario Delgado Antoni Riera Maria J. Macias |
| author_facet |
Álvaro Rol Toni Todorovski Pau Martin-Malpartida Anna Escolà Elena Gonzalez-Rey Eric Aragón Xavier Verdaguer Mariona Vallès-Miret Josep Farrera-Sinfreu Eduard Puig Jimena Fernández-Carneado Berta Ponsati Mario Delgado Antoni Riera Maria J. Macias |
| author_sort |
Álvaro Rol |
| title |
Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease |
| title_short |
Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease |
| title_full |
Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease |
| title_fullStr |
Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease |
| title_full_unstemmed |
Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease |
| title_sort |
structure-based design of a cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/538094955b874388ace1e053acd30f22 |
| work_keys_str_mv |
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