Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen

Developing broadly applicable neoantigen-directed adoptive cell therapies (ACTs) is challenging because each cancer patient has an unique neoantigen repertoire. Here, the authors present the crystal structures of tumor-specific T cell receptors (TCRs) that recognize a shared neoepitope arising from...

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Auteurs principaux: Daichao Wu, D. Travis Gallagher, Ragul Gowthaman, Brian G. Pierce, Roy A. Mariuzza
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/539421cdbf2649ba84e049f00249ee1a
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