Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs

Paternal environmental inputs can influence various phenotypes in offspring, with important implications for basic biology and public health. Here the authors show that Ang-mediated biogenesis of 5′-tsRNAs in sperm contributes to paternal inflammation-induced metabolic disorders in offspring.

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Autores principales: Yanwen Zhang, Li Ren, Xiaoxiao Sun, Zhilong Zhang, Jie Liu, Yining Xin, Jianmin Yu, Yimin Jia, Jinghao Sheng, Guo-fu Hu, Ruqian Zhao, Bin He
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/53aabb0785ef48efaf1f35fe61011e0a
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