Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs

Paternal environmental inputs can influence various phenotypes in offspring, with important implications for basic biology and public health. Here the authors show that Ang-mediated biogenesis of 5′-tsRNAs in sperm contributes to paternal inflammation-induced metabolic disorders in offspring.

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Autores principales:	Yanwen Zhang, Li Ren, Xiaoxiao Sun, Zhilong Zhang, Jie Liu, Yining Xin, Jianmin Yu, Yimin Jia, Jinghao Sheng, Guo-fu Hu, Ruqian Zhao, Bin He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53aabb0785ef48efaf1f35fe61011e0a
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spelling	oai:doaj.org-article:53aabb0785ef48efaf1f35fe61011e0a2021-12-05T12:23:14ZAngiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs10.1038/s41467-021-26909-12041-1723https://doaj.org/article/53aabb0785ef48efaf1f35fe61011e0a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26909-1https://doaj.org/toc/2041-1723Paternal environmental inputs can influence various phenotypes in offspring, with important implications for basic biology and public health. Here the authors show that Ang-mediated biogenesis of 5′-tsRNAs in sperm contributes to paternal inflammation-induced metabolic disorders in offspring.Yanwen ZhangLi RenXiaoxiao SunZhilong ZhangJie LiuYining XinJianmin YuYimin JiaJinghao ShengGuo-fu HuRuqian ZhaoBin HeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yanwen Zhang Li Ren Xiaoxiao Sun Zhilong Zhang Jie Liu Yining Xin Jianmin Yu Yimin Jia Jinghao Sheng Guo-fu Hu Ruqian Zhao Bin He Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs
description	Paternal environmental inputs can influence various phenotypes in offspring, with important implications for basic biology and public health. Here the authors show that Ang-mediated biogenesis of 5′-tsRNAs in sperm contributes to paternal inflammation-induced metabolic disorders in offspring.
format	article
author	Yanwen Zhang Li Ren Xiaoxiao Sun Zhilong Zhang Jie Liu Yining Xin Jianmin Yu Yimin Jia Jinghao Sheng Guo-fu Hu Ruqian Zhao Bin He
author_facet	Yanwen Zhang Li Ren Xiaoxiao Sun Zhilong Zhang Jie Liu Yining Xin Jianmin Yu Yimin Jia Jinghao Sheng Guo-fu Hu Ruqian Zhao Bin He
author_sort	Yanwen Zhang
title	Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs
title_short	Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs
title_full	Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs
title_fullStr	Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs
title_full_unstemmed	Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs
title_sort	angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsrnas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/53aabb0785ef48efaf1f35fe61011e0a
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Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs

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