Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification

Iron metabolism is linked to type 2 diabetes. Here the authors describe a mechanism through which cellular iron deficiency caused by loss of Irp2 impairs Cdkal1 function, resulting in inaccurate proinsulin translation, impaired proinsulin processing and reduced insulin secretion.

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Detalles Bibliográficos
Autores principales:	Maria C. Ferreira dos Santos, Cole P. Anderson, Susanne Neschen, Kimberly B. Zumbrennen-Bullough, Steven J. Romney, Melanie Kahle-Stephan, Birgit Rathkolb, Valerie Gailus-Durner, Helmut Fuchs, Eckhard Wolf, Jan Rozman, Martin Hrabe de Angelis, Weiling Maggie Cai, Malini Rajan, Jennifer Hu, Peter C. Dedon, Elizabeth A. Leibold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53f26f3f35f1461a9fc51b7c51673141
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spelling	oai:doaj.org-article:53f26f3f35f1461a9fc51b7c516731412021-12-02T15:39:27ZIrp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification10.1038/s41467-019-14004-52041-1723https://doaj.org/article/53f26f3f35f1461a9fc51b7c516731412020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14004-5https://doaj.org/toc/2041-1723Iron metabolism is linked to type 2 diabetes. Here the authors describe a mechanism through which cellular iron deficiency caused by loss of Irp2 impairs Cdkal1 function, resulting in inaccurate proinsulin translation, impaired proinsulin processing and reduced insulin secretion.Maria C. Ferreira dos SantosCole P. AndersonSusanne NeschenKimberly B. Zumbrennen-BulloughSteven J. RomneyMelanie Kahle-StephanBirgit RathkolbValerie Gailus-DurnerHelmut FuchsEckhard WolfJan RozmanMartin Hrabe de AngelisWeiling Maggie CaiMalini RajanJennifer HuPeter C. DedonElizabeth A. LeiboldNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria C. Ferreira dos Santos Cole P. Anderson Susanne Neschen Kimberly B. Zumbrennen-Bullough Steven J. Romney Melanie Kahle-Stephan Birgit Rathkolb Valerie Gailus-Durner Helmut Fuchs Eckhard Wolf Jan Rozman Martin Hrabe de Angelis Weiling Maggie Cai Malini Rajan Jennifer Hu Peter C. Dedon Elizabeth A. Leibold Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
description	Iron metabolism is linked to type 2 diabetes. Here the authors describe a mechanism through which cellular iron deficiency caused by loss of Irp2 impairs Cdkal1 function, resulting in inaccurate proinsulin translation, impaired proinsulin processing and reduced insulin secretion.
format	article
author	Maria C. Ferreira dos Santos Cole P. Anderson Susanne Neschen Kimberly B. Zumbrennen-Bullough Steven J. Romney Melanie Kahle-Stephan Birgit Rathkolb Valerie Gailus-Durner Helmut Fuchs Eckhard Wolf Jan Rozman Martin Hrabe de Angelis Weiling Maggie Cai Malini Rajan Jennifer Hu Peter C. Dedon Elizabeth A. Leibold
author_facet	Maria C. Ferreira dos Santos Cole P. Anderson Susanne Neschen Kimberly B. Zumbrennen-Bullough Steven J. Romney Melanie Kahle-Stephan Birgit Rathkolb Valerie Gailus-Durner Helmut Fuchs Eckhard Wolf Jan Rozman Martin Hrabe de Angelis Weiling Maggie Cai Malini Rajan Jennifer Hu Peter C. Dedon Elizabeth A. Leibold
author_sort	Maria C. Ferreira dos Santos
title	Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
title_short	Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
title_full	Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
title_fullStr	Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
title_full_unstemmed	Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
title_sort	irp2 regulates insulin production through iron-mediated cdkal1-catalyzed trna modification
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/53f26f3f35f1461a9fc51b7c51673141
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Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification

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