Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification

Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification

Iron metabolism is linked to type 2 diabetes. Here the authors describe a mechanism through which cellular iron deficiency caused by loss of Irp2 impairs Cdkal1 function, resulting in inaccurate proinsulin translation, impaired proinsulin processing and reduced insulin secretion.

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Auteurs principaux: Maria C. Ferreira dos Santos, Cole P. Anderson, Susanne Neschen, Kimberly B. Zumbrennen-Bullough, Steven J. Romney, Melanie Kahle-Stephan, Birgit Rathkolb, Valerie Gailus-Durner, Helmut Fuchs, Eckhard Wolf, Jan Rozman, Martin Hrabe de Angelis, Weiling Maggie Cai, Malini Rajan, Jennifer Hu, Peter C. Dedon, Elizabeth A. Leibold
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Science
Q
Accès en ligne:https://doaj.org/article/53f26f3f35f1461a9fc51b7c51673141
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Internet

https://doaj.org/article/53f26f3f35f1461a9fc51b7c51673141

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