Development of Indole Alkaloid-Type Dual Immune Checkpoint Inhibitors Against CTLA-4 and PD-L1 Based on Diversity-Enhanced Extracts

Development of Indole Alkaloid-Type Dual Immune Checkpoint Inhibitors Against CTLA-4 and PD-L1 Based on Diversity-Enhanced Extracts

Cancer immunotherapy involves the use of the immune system for cancer treatment. Recently, immune checkpoint-blocking antibodies have become integral for the treatment of some cancers. However, small molecules exhibit advantages over monoclonal antibody drugs, such as cell penetration, long half-lif...

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Autores principales: Yoshihide Suzuki, Keisuke Ichinohe, Akihiro Sugawara, Shinya Kida, Shinya Murase, Jing Zhang, Osamu Yamada, Toshio Hattori, Yoshiteru Oshima, Haruhisa Kikuchi
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
immune checkpoint inhibitors
natural products
indole
PD-L1
CTLA-4
diversity-enhanced extracts
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/5446e2a977fb434dabf63311a85d4f08
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https://doaj.org/article/5446e2a977fb434dabf63311a85d4f08

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