Single-Cell Analysis of the Plasmablast Response to <named-content content-type="genus-species">Vibrio cholerae</named-content> Demonstrates Expansion of Cross-Reactive Memory B Cells

Single-Cell Analysis of the Plasmablast Response to <named-content content-type="genus-species">Vibrio cholerae</named-content> Demonstrates Expansion of Cross-Reactive Memory B Cells

ABSTRACT We characterized the acute B cell response in adults with cholera by analyzing the repertoire, specificity, and functional characteristics of 138 monoclonal antibodies (MAbs) generated from single-cell-sorted plasmablasts. We found that the cholera-induced responses were characterized by hi...

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Main Authors: Robert C. Kauffman, Taufiqur R. Bhuiyan, Rie Nakajima, Leslie M. Mayo-Smith, Rasheduzzaman Rashu, Mohammad Rubel Hoq, Fahima Chowdhury, Ashraful Islam Khan, Atiqur Rahman, Siddhartha K. Bhaumik, Levelle Harris, Justin T. O'Neal, Jessica F. Trost, Nur Haq Alam, Algis Jasinskas, Emmanuel Dotsey, Meagan Kelly, Richelle C. Charles, Peng Xu, Pavol Kováč, Stephen B. Calderwood, Edward T. Ryan, Phillip L. Felgner, Firdausi Qadri, Jens Wrammert, Jason B. Harris
Format: article
Language:EN
Published: American Society for Microbiology 2016
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/545c93248a4d4ab2b5a66d76c072274b
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https://doaj.org/article/545c93248a4d4ab2b5a66d76c072274b

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