Atomic-level differences between brain parenchymal- and cerebrovascular-seeded Aβ fibrils

Abstract Alzheimer’s disease is characterized by neuritic plaques, the main protein components of which are β-amyloid (Aβ) peptides deposited as β-sheet-rich amyloid fibrils. Cerebral Amyloid Angiopathy (CAA) consists of cerebrovascular deposits of Aβ peptides; it usually accompanies Alzheimer’s dis...

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Autores principales: Kathryn P. Scherpelz, Songlin Wang, Peter Pytel, Rama S. Madhurapantula, Atul K. Srivastava, Joseph R. Sachleben, Joseph Orgel, Yoshitaka Ishii, Stephen C. Meredith
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/549a89f7338448fd9a222cd6a6278088
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