Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch

TRPV1 channels are known to mediate pathological pain and itch. Here, the authors find a naturally occurring fatty acid, oleic acid, acts as a TRPV1 antagonist and can modulate capsaicin and histamine-mediated pain and itch response in mouse models.

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Autores principales:	Sara L. Morales-Lázaro, Itzel Llorente, Félix Sierra-Ramírez, Ana E. López-Romero, Miguel Ortíz-Rentería, Barbara Serrano-Flores, Sidney A. Simon, León D. Islas, Tamara Rosenbaum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54aa5cbb43274e3e806447b790722427
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spelling	oai:doaj.org-article:54aa5cbb43274e3e806447b7907224272021-12-02T16:56:45ZInhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch10.1038/ncomms130922041-1723https://doaj.org/article/54aa5cbb43274e3e806447b7907224272016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13092https://doaj.org/toc/2041-1723TRPV1 channels are known to mediate pathological pain and itch. Here, the authors find a naturally occurring fatty acid, oleic acid, acts as a TRPV1 antagonist and can modulate capsaicin and histamine-mediated pain and itch response in mouse models.Sara L. Morales-LázaroItzel LlorenteFélix Sierra-RamírezAna E. López-RomeroMiguel Ortíz-RenteríaBarbara Serrano-FloresSidney A. SimonLeón D. IslasTamara RosenbaumNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara L. Morales-Lázaro Itzel Llorente Félix Sierra-Ramírez Ana E. López-Romero Miguel Ortíz-Rentería Barbara Serrano-Flores Sidney A. Simon León D. Islas Tamara Rosenbaum Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch
description	TRPV1 channels are known to mediate pathological pain and itch. Here, the authors find a naturally occurring fatty acid, oleic acid, acts as a TRPV1 antagonist and can modulate capsaicin and histamine-mediated pain and itch response in mouse models.
format	article
author	Sara L. Morales-Lázaro Itzel Llorente Félix Sierra-Ramírez Ana E. López-Romero Miguel Ortíz-Rentería Barbara Serrano-Flores Sidney A. Simon León D. Islas Tamara Rosenbaum
author_facet	Sara L. Morales-Lázaro Itzel Llorente Félix Sierra-Ramírez Ana E. López-Romero Miguel Ortíz-Rentería Barbara Serrano-Flores Sidney A. Simon León D. Islas Tamara Rosenbaum
author_sort	Sara L. Morales-Lázaro
title	Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch
title_short	Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch
title_full	Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch
title_fullStr	Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch
title_full_unstemmed	Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch
title_sort	inhibition of trpv1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/54aa5cbb43274e3e806447b790722427
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Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch

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