HIF1A signaling selectively supports proliferation of breast cancer in the brain

The mechanisms underlying the growth of breast cancer metastasis in the brain are unclear. Here, the authors use an intracranial injection mouse model and single-cell analysis of patient circulating tumour cells to demonstrate that increased hypoxic and HIF1A signalling promotes tumour growth in the...

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Autores principales:	Richard Y. Ebright, Marcus A. Zachariah, Douglas S. Micalizzi, Ben S. Wittner, Kira L. Niederhoffer, Linda T. Nieman, Brian Chirn, Devon F. Wiley, Benjamin Wesley, Brian Shaw, Edwin Nieblas-Bedolla, Lian Atlas, Annamaria Szabolcs, Anthony J. Iafrate, Mehmet Toner, David T. Ting, Priscilla K. Brastianos, Daniel A. Haber, Shyamala Maheswaran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54abe4889e2240aa9d1bd7861d09df2e
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spelling	oai:doaj.org-article:54abe4889e2240aa9d1bd7861d09df2e2021-12-02T10:48:10ZHIF1A signaling selectively supports proliferation of breast cancer in the brain10.1038/s41467-020-20144-w2041-1723https://doaj.org/article/54abe4889e2240aa9d1bd7861d09df2e2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20144-whttps://doaj.org/toc/2041-1723The mechanisms underlying the growth of breast cancer metastasis in the brain are unclear. Here, the authors use an intracranial injection mouse model and single-cell analysis of patient circulating tumour cells to demonstrate that increased hypoxic and HIF1A signalling promotes tumour growth in the brain.Richard Y. EbrightMarcus A. ZachariahDouglas S. MicalizziBen S. WittnerKira L. NiederhofferLinda T. NiemanBrian ChirnDevon F. WileyBenjamin WesleyBrian ShawEdwin Nieblas-BedollaLian AtlasAnnamaria SzabolcsAnthony J. IafrateMehmet TonerDavid T. TingPriscilla K. BrastianosDaniel A. HaberShyamala MaheswaranNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Richard Y. Ebright Marcus A. Zachariah Douglas S. Micalizzi Ben S. Wittner Kira L. Niederhoffer Linda T. Nieman Brian Chirn Devon F. Wiley Benjamin Wesley Brian Shaw Edwin Nieblas-Bedolla Lian Atlas Annamaria Szabolcs Anthony J. Iafrate Mehmet Toner David T. Ting Priscilla K. Brastianos Daniel A. Haber Shyamala Maheswaran HIF1A signaling selectively supports proliferation of breast cancer in the brain
description	The mechanisms underlying the growth of breast cancer metastasis in the brain are unclear. Here, the authors use an intracranial injection mouse model and single-cell analysis of patient circulating tumour cells to demonstrate that increased hypoxic and HIF1A signalling promotes tumour growth in the brain.
format	article
author	Richard Y. Ebright Marcus A. Zachariah Douglas S. Micalizzi Ben S. Wittner Kira L. Niederhoffer Linda T. Nieman Brian Chirn Devon F. Wiley Benjamin Wesley Brian Shaw Edwin Nieblas-Bedolla Lian Atlas Annamaria Szabolcs Anthony J. Iafrate Mehmet Toner David T. Ting Priscilla K. Brastianos Daniel A. Haber Shyamala Maheswaran
author_facet	Richard Y. Ebright Marcus A. Zachariah Douglas S. Micalizzi Ben S. Wittner Kira L. Niederhoffer Linda T. Nieman Brian Chirn Devon F. Wiley Benjamin Wesley Brian Shaw Edwin Nieblas-Bedolla Lian Atlas Annamaria Szabolcs Anthony J. Iafrate Mehmet Toner David T. Ting Priscilla K. Brastianos Daniel A. Haber Shyamala Maheswaran
author_sort	Richard Y. Ebright
title	HIF1A signaling selectively supports proliferation of breast cancer in the brain
title_short	HIF1A signaling selectively supports proliferation of breast cancer in the brain
title_full	HIF1A signaling selectively supports proliferation of breast cancer in the brain
title_fullStr	HIF1A signaling selectively supports proliferation of breast cancer in the brain
title_full_unstemmed	HIF1A signaling selectively supports proliferation of breast cancer in the brain
title_sort	hif1a signaling selectively supports proliferation of breast cancer in the brain
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/54abe4889e2240aa9d1bd7861d09df2e
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HIF1A signaling selectively supports proliferation of breast cancer in the brain

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