HIF1A signaling selectively supports proliferation of breast cancer in the brain

HIF1A signaling selectively supports proliferation of breast cancer in the brain

The mechanisms underlying the growth of breast cancer metastasis in the brain are unclear. Here, the authors use an intracranial injection mouse model and single-cell analysis of patient circulating tumour cells to demonstrate that increased hypoxic and HIF1A signalling promotes tumour growth in the...

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Autores principales: Richard Y. Ebright, Marcus A. Zachariah, Douglas S. Micalizzi, Ben S. Wittner, Kira L. Niederhoffer, Linda T. Nieman, Brian Chirn, Devon F. Wiley, Benjamin Wesley, Brian Shaw, Edwin Nieblas-Bedolla, Lian Atlas, Annamaria Szabolcs, Anthony J. Iafrate, Mehmet Toner, David T. Ting, Priscilla K. Brastianos, Daniel A. Haber, Shyamala Maheswaran
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/54abe4889e2240aa9d1bd7861d09df2e
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