MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

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MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

Wnt signaling is necessary for colorectal cancer tumorigenesis and stem cell maintenance. Here, the authors identify MEK1/2 inhibitors as potent activators of Wnt/β-catenin signalling and show that clinically approved MEK inhibitors inadvertently induce stem cell plasticity in colorectal cancer

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Détails bibliographiques
Auteurs principaux:	Tianzuo Zhan, Giulia Ambrosi, Anna Maxi Wandmacher, Benedikt Rauscher, Johannes Betge, Niklas Rindtorff, Ragna S. Häussler, Isabel Hinsenkamp, Leonhard Bamberg, Bernd Hessling, Karin Müller-Decker, Gerrit Erdmann, Elke Burgermeister, Matthias P. Ebert, Michael Boutros
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/54b4ea38523f4011a819f580a23a3c55
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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