Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema.

Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema.

<h4>Background</h4>In this study we set out to investigate the clinically observed relationship between chronic obstructive pulmonary disease (COPD) and aortic aneurysms. We tested the hypothesis that an inherited deficiency of connective tissue might play a role in the combined developm...

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Auteurs principaux: Natasja W M Ramnath, Koen M van de Luijtgaarden, Ingrid van der Pluijm, Menno van Nimwegen, Paula M van Heijningen, Sigrid M A Swagemakers, Bibi S van Thiel, Ruziedi Y Ridwan, Nicole van Vliet, Marcel Vermeij, Luuk J A C Hawinkels, Anne de Munck, Oleh Dzyubachyk, Erik Meijering, Peter van der Spek, Robbert Rottier, Hiromi Yanagisawa, Rudi W Hendriks, Roland Kanaar, Ellen V Rouwet, Alex Kleinjan, Jeroen Essers
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2014
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/54e4a897fc8f4940a384b4aa95d8a42b
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