An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases

Successful anticancer immunotherapy should induce robust systemic immunity against metastases. Here, the authors engineer an inhalable nano-STING agonist, which synergizes with fractionated radiation to control lung metastases and confers long-term systemic antitumor immunity in mice.

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Autores principales:	Yang Liu, William N. Crowe, Lulu Wang, Yong Lu, W. Jeffrey Petty, Amyn A. Habib, Dawen Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54ebf73015d9478d882dbc5a6522a5e5
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spelling	oai:doaj.org-article:54ebf73015d9478d882dbc5a6522a5e52021-12-02T17:01:36ZAn inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases10.1038/s41467-019-13094-52041-1723https://doaj.org/article/54ebf73015d9478d882dbc5a6522a5e52019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13094-5https://doaj.org/toc/2041-1723Successful anticancer immunotherapy should induce robust systemic immunity against metastases. Here, the authors engineer an inhalable nano-STING agonist, which synergizes with fractionated radiation to control lung metastases and confers long-term systemic antitumor immunity in mice.Yang LiuWilliam N. CroweLulu WangYong LuW. Jeffrey PettyAmyn A. HabibDawen ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang Liu William N. Crowe Lulu Wang Yong Lu W. Jeffrey Petty Amyn A. Habib Dawen Zhao An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases
description	Successful anticancer immunotherapy should induce robust systemic immunity against metastases. Here, the authors engineer an inhalable nano-STING agonist, which synergizes with fractionated radiation to control lung metastases and confers long-term systemic antitumor immunity in mice.
format	article
author	Yang Liu William N. Crowe Lulu Wang Yong Lu W. Jeffrey Petty Amyn A. Habib Dawen Zhao
author_facet	Yang Liu William N. Crowe Lulu Wang Yong Lu W. Jeffrey Petty Amyn A. Habib Dawen Zhao
author_sort	Yang Liu
title	An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases
title_short	An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases
title_full	An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases
title_fullStr	An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases
title_full_unstemmed	An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases
title_sort	inhalable nanoparticulate sting agonist synergizes with radiotherapy to confer long-term control of lung metastases
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/54ebf73015d9478d882dbc5a6522a5e5
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An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases

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