Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin
The α-toxin LqhIII from the deathstalker scorpion inhibits fast inactivation of cardiac NaV1.5 channels. Here authors reveal the cryo-EM structure of LqhIII bound to NaV1.5 which shows that LqhIII traps the gating charges of the S4 segment in a unique intermediate-activated state and explains why Lq...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/551ce5bc8824402bb013e154205ef0bc |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|