Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

The α-toxin LqhIII from the deathstalker scorpion inhibits fast inactivation of cardiac NaV1.5 channels. Here authors reveal the cryo-EM structure of LqhIII bound to NaV1.5 which shows that LqhIII traps the gating charges of the S4 segment in a unique intermediate-activated state and explains why Lq...

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Autores principales:	Daohua Jiang, Lige Tonggu, Tamer M. Gamal El-Din, Richard Banh, Régis Pomès, Ning Zheng, William A. Catterall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/551ce5bc8824402bb013e154205ef0bc
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spelling	oai:doaj.org-article:551ce5bc8824402bb013e154205ef0bc2021-12-02T15:16:23ZStructural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin10.1038/s41467-020-20078-32041-1723https://doaj.org/article/551ce5bc8824402bb013e154205ef0bc2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20078-3https://doaj.org/toc/2041-1723The α-toxin LqhIII from the deathstalker scorpion inhibits fast inactivation of cardiac NaV1.5 channels. Here authors reveal the cryo-EM structure of LqhIII bound to NaV1.5 which shows that LqhIII traps the gating charges of the S4 segment in a unique intermediate-activated state and explains why LqhIII slows inactivation of NaV channels but does not open them.Daohua JiangLige TongguTamer M. Gamal El-DinRichard BanhRégis PomèsNing ZhengWilliam A. CatterallNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daohua Jiang Lige Tonggu Tamer M. Gamal El-Din Richard Banh Régis Pomès Ning Zheng William A. Catterall Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin
description	The α-toxin LqhIII from the deathstalker scorpion inhibits fast inactivation of cardiac NaV1.5 channels. Here authors reveal the cryo-EM structure of LqhIII bound to NaV1.5 which shows that LqhIII traps the gating charges of the S4 segment in a unique intermediate-activated state and explains why LqhIII slows inactivation of NaV channels but does not open them.
format	article
author	Daohua Jiang Lige Tonggu Tamer M. Gamal El-Din Richard Banh Régis Pomès Ning Zheng William A. Catterall
author_facet	Daohua Jiang Lige Tonggu Tamer M. Gamal El-Din Richard Banh Régis Pomès Ning Zheng William A. Catterall
author_sort	Daohua Jiang
title	Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin
title_short	Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin
title_full	Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin
title_fullStr	Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin
title_full_unstemmed	Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin
title_sort	structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/551ce5bc8824402bb013e154205ef0bc
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Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

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