Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

The α-toxin LqhIII from the deathstalker scorpion inhibits fast inactivation of cardiac NaV1.5 channels. Here authors reveal the cryo-EM structure of LqhIII bound to NaV1.5 which shows that LqhIII traps the gating charges of the S4 segment in a unique intermediate-activated state and explains why Lq...

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Autores principales: Daohua Jiang, Lige Tonggu, Tamer M. Gamal El-Din, Richard Banh, Régis Pomès, Ning Zheng, William A. Catterall
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/551ce5bc8824402bb013e154205ef0bc
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