Mechanistic principles of an ultra-long bovine CDR reveal strategies for antibody design
Certain bovine antibodies have ultra-long long complementarity-determining regions (CDRs) that contain a knob for antigen interaction, which is connected to the antibody through a stalk. Here, the authors combine biophysical experiments and MD simulations and show that the stalk length is critical f...
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Autores principales: | Hristo L. Svilenov, Julia Sacherl, Ulrike Protzer, Martin Zacharias, Johannes Buchner |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/551d369430b84beb8602ae26a8e6b65f |
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