A nanofluidic knot factory based on compression of single DNA in nanochannels

Polymer knots are important for a range of biological systems and engineering applications, yet the variables influencing knotting probability are not well understood. Here the authors develop a nanofluidic device that can detect knots and provide a free energy formalism that can quantify knotting p...

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Autores principales:	Susan Amin, Ahmed Khorshid, Lili Zeng, Philip Zimny, Walter Reisner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/552bcbf1667d4397b0fb09d55e482b45
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spelling	oai:doaj.org-article:552bcbf1667d4397b0fb09d55e482b452021-12-02T16:56:59ZA nanofluidic knot factory based on compression of single DNA in nanochannels10.1038/s41467-018-03901-w2041-1723https://doaj.org/article/552bcbf1667d4397b0fb09d55e482b452018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03901-whttps://doaj.org/toc/2041-1723Polymer knots are important for a range of biological systems and engineering applications, yet the variables influencing knotting probability are not well understood. Here the authors develop a nanofluidic device that can detect knots and provide a free energy formalism that can quantify knotting probability in their system.Susan AminAhmed KhorshidLili ZengPhilip ZimnyWalter ReisnerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Susan Amin Ahmed Khorshid Lili Zeng Philip Zimny Walter Reisner A nanofluidic knot factory based on compression of single DNA in nanochannels
description	Polymer knots are important for a range of biological systems and engineering applications, yet the variables influencing knotting probability are not well understood. Here the authors develop a nanofluidic device that can detect knots and provide a free energy formalism that can quantify knotting probability in their system.
format	article
author	Susan Amin Ahmed Khorshid Lili Zeng Philip Zimny Walter Reisner
author_facet	Susan Amin Ahmed Khorshid Lili Zeng Philip Zimny Walter Reisner
author_sort	Susan Amin
title	A nanofluidic knot factory based on compression of single DNA in nanochannels
title_short	A nanofluidic knot factory based on compression of single DNA in nanochannels
title_full	A nanofluidic knot factory based on compression of single DNA in nanochannels
title_fullStr	A nanofluidic knot factory based on compression of single DNA in nanochannels
title_full_unstemmed	A nanofluidic knot factory based on compression of single DNA in nanochannels
title_sort	nanofluidic knot factory based on compression of single dna in nanochannels
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/552bcbf1667d4397b0fb09d55e482b45
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A nanofluidic knot factory based on compression of single DNA in nanochannels

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