Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals

Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals

Abstract Background Precise gene dosage of the X chromosomes is critical for normal development and cellular function. In mice, XX female somatic cells show transcriptional X chromosome upregulation of their single active X chromosome, while the other X chromosome is inactive. Moreover, the inactive...

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Main Authors: Irene Talon, Adrian Janiszewski, Bart Theeuwes, Thomas Lefevre, Juan Song, Greet Bervoets, Lotte Vanheer, Natalie De Geest, Suresh Poovathingal, Ryan Allsop, Jean-Christophe Marine, Florian Rambow, Thierry Voet, Vincent Pasque
Format: article
Language:EN
Published: BMC 2021
Subjects:
X chromosome upregulation
X chromosome reactivation
Chromatin accessibility
Gene regulatory networks
iPSC reprogramming
Gene dosage compensation
Biology (General)
QH301-705.5
Genetics
QH426-470
Online Access:https://doaj.org/article/553698c5364b4b4abcd02d2908aac7a2
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https://doaj.org/article/553698c5364b4b4abcd02d2908aac7a2

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