Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals
Abstract Background Precise gene dosage of the X chromosomes is critical for normal development and cellular function. In mice, XX female somatic cells show transcriptional X chromosome upregulation of their single active X chromosome, while the other X chromosome is inactive. Moreover, the inactive...
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Main Authors: | Irene Talon, Adrian Janiszewski, Bart Theeuwes, Thomas Lefevre, Juan Song, Greet Bervoets, Lotte Vanheer, Natalie De Geest, Suresh Poovathingal, Ryan Allsop, Jean-Christophe Marine, Florian Rambow, Thierry Voet, Vincent Pasque |
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Format: | article |
Language: | EN |
Published: |
BMC
2021
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Online Access: | https://doaj.org/article/553698c5364b4b4abcd02d2908aac7a2 |
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