Developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners.

TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin, commonly known as dioxin) is a ubiquitous environmental contaminant and known endocrine disruptor. Using a mouse model, we previously found that adult female mice exposed in utero to TCDD (F1 generation) as well as multiple subsequent generations (F2-F4) ex...

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Autores principales:	Kaylon L Bruner-Tran, Tianbing Ding, Kallie B Yeoman, Anthony Archibong, Joe A Arosh, Kevin G Osteen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/55511374c7a244a68506538589080e25
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spelling	oai:doaj.org-article:55511374c7a244a68506538589080e252021-11-25T06:04:37ZDevelopmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners.1932-620310.1371/journal.pone.0105084https://doaj.org/article/55511374c7a244a68506538589080e252014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25127480/?tool=EBIhttps://doaj.org/toc/1932-6203TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin, commonly known as dioxin) is a ubiquitous environmental contaminant and known endocrine disruptor. Using a mouse model, we previously found that adult female mice exposed in utero to TCDD (F1 generation) as well as multiple subsequent generations (F2-F4) exhibited reduced fertility and an increased incidence of spontaneous preterm birth. Additional studies revealed that male F1 mice with a similar in utero/developmental TCDD exposure also exhibited diminished fertility and conferred an increased risk of preterm birth to their unexposed mating partners. Herein, we extend these previous observations, reporting that reduced fertility in male F1 mice is linked to testicular inflammation which coincides with apoptosis of developing spermatocytes, sub-fertility and an increased risk of preterm birth in their unexposed mating partners. Significantly, in the absence of additional toxicant exposure, testicular inflammation and reduced fertility persisted in F2 and F3 males and their control mating partners also frequently exhibited spontaneous preterm birth. Although a steady, global decline in male fertility has been noted over the last few decades, the reasons for these changes have not been firmly established. Likewise, the PTB rate in the U.S. and other countries has paralleled industrial development, suggesting a possible relationship between environmental toxicant exposure and adverse pregnancy outcomes. Most current clinical strategies to prevent preterm birth are focused solely on the mother and have yielded limited benefits. In contrast, our studies strongly suggest that the preconception testicular health of the father is a critical determinant of pregnancy outcomes in mice. Future clinical studies should examine the potential contribution of the male to gestation length in women and whether efforts to reduce the incidence of preterm birth should be initiated in both parents prior to pregnancy.Kaylon L Bruner-TranTianbing DingKallie B YeomanAnthony ArchibongJoe A AroshKevin G OsteenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105084 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kaylon L Bruner-Tran Tianbing Ding Kallie B Yeoman Anthony Archibong Joe A Arosh Kevin G Osteen Developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners.
description	TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin, commonly known as dioxin) is a ubiquitous environmental contaminant and known endocrine disruptor. Using a mouse model, we previously found that adult female mice exposed in utero to TCDD (F1 generation) as well as multiple subsequent generations (F2-F4) exhibited reduced fertility and an increased incidence of spontaneous preterm birth. Additional studies revealed that male F1 mice with a similar in utero/developmental TCDD exposure also exhibited diminished fertility and conferred an increased risk of preterm birth to their unexposed mating partners. Herein, we extend these previous observations, reporting that reduced fertility in male F1 mice is linked to testicular inflammation which coincides with apoptosis of developing spermatocytes, sub-fertility and an increased risk of preterm birth in their unexposed mating partners. Significantly, in the absence of additional toxicant exposure, testicular inflammation and reduced fertility persisted in F2 and F3 males and their control mating partners also frequently exhibited spontaneous preterm birth. Although a steady, global decline in male fertility has been noted over the last few decades, the reasons for these changes have not been firmly established. Likewise, the PTB rate in the U.S. and other countries has paralleled industrial development, suggesting a possible relationship between environmental toxicant exposure and adverse pregnancy outcomes. Most current clinical strategies to prevent preterm birth are focused solely on the mother and have yielded limited benefits. In contrast, our studies strongly suggest that the preconception testicular health of the father is a critical determinant of pregnancy outcomes in mice. Future clinical studies should examine the potential contribution of the male to gestation length in women and whether efforts to reduce the incidence of preterm birth should be initiated in both parents prior to pregnancy.
format	article
author	Kaylon L Bruner-Tran Tianbing Ding Kallie B Yeoman Anthony Archibong Joe A Arosh Kevin G Osteen
author_facet	Kaylon L Bruner-Tran Tianbing Ding Kallie B Yeoman Anthony Archibong Joe A Arosh Kevin G Osteen
author_sort	Kaylon L Bruner-Tran
title	Developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners.
title_short	Developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners.
title_full	Developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners.
title_fullStr	Developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners.
title_full_unstemmed	Developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners.
title_sort	developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/55511374c7a244a68506538589080e25
work_keys_str_mv	AT kaylonlbrunertran developmentalexposureofmicetodioxinpromotestransgenerationaltesticularinflammationandanincreasedriskofpretermbirthinunexposedmatingpartners AT tianbingding developmentalexposureofmicetodioxinpromotestransgenerationaltesticularinflammationandanincreasedriskofpretermbirthinunexposedmatingpartners AT kalliebyeoman developmentalexposureofmicetodioxinpromotestransgenerationaltesticularinflammationandanincreasedriskofpretermbirthinunexposedmatingpartners AT anthonyarchibong developmentalexposureofmicetodioxinpromotestransgenerationaltesticularinflammationandanincreasedriskofpretermbirthinunexposedmatingpartners AT joeaarosh developmentalexposureofmicetodioxinpromotestransgenerationaltesticularinflammationandanincreasedriskofpretermbirthinunexposedmatingpartners AT kevingosteen developmentalexposureofmicetodioxinpromotestransgenerationaltesticularinflammationandanincreasedriskofpretermbirthinunexposedmatingpartners
_version_	1718414223029043200

Developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners.

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