Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy

Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy

High-affinity IL-2Rα expressed by Tregs mitigates the potential of IL-2 use in cancer therapy. Here, the authors fuse IL-2 with an NKDG2 binding domain, and show that it induces IL-2 signalling selectively in NKG2D+cells, delaying tumour growth in mice without the side effects of conventional IL-2 t...

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Main Authors: Reza Ghasemi, Eric Lazear, Xiaoli Wang, Saeed Arefanian, Alexander Zheleznyak, Beatriz M. Carreno, Ryuji Higashikubo, Andrew E. Gelman, Daniel Kreisel, Daved H. Fremont, Alexander Sasha Krupnick
Format: article
Language:EN
Published: Nature Portfolio 2016
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Science
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Online Access:https://doaj.org/article/556e5f18a8074910ad3823823e1bf265
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https://doaj.org/article/556e5f18a8074910ad3823823e1bf265

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