Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy

High-affinity IL-2Rα expressed by Tregs mitigates the potential of IL-2 use in cancer therapy. Here, the authors fuse IL-2 with an NKDG2 binding domain, and show that it induces IL-2 signalling selectively in NKG2D+cells, delaying tumour growth in mice without the side effects of conventional IL-2 t...

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Autores principales:	Reza Ghasemi, Eric Lazear, Xiaoli Wang, Saeed Arefanian, Alexander Zheleznyak, Beatriz M. Carreno, Ryuji Higashikubo, Andrew E. Gelman, Daniel Kreisel, Daved H. Fremont, Alexander Sasha Krupnick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/556e5f18a8074910ad3823823e1bf265
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spelling	oai:doaj.org-article:556e5f18a8074910ad3823823e1bf2652021-12-02T17:31:48ZSelective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy10.1038/ncomms128782041-1723https://doaj.org/article/556e5f18a8074910ad3823823e1bf2652016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12878https://doaj.org/toc/2041-1723High-affinity IL-2Rα expressed by Tregs mitigates the potential of IL-2 use in cancer therapy. Here, the authors fuse IL-2 with an NKDG2 binding domain, and show that it induces IL-2 signalling selectively in NKG2D+cells, delaying tumour growth in mice without the side effects of conventional IL-2 therapy.Reza GhasemiEric LazearXiaoli WangSaeed ArefanianAlexander ZheleznyakBeatriz M. CarrenoRyuji HigashikuboAndrew E. GelmanDaniel KreiselDaved H. FremontAlexander Sasha KrupnickNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Reza Ghasemi Eric Lazear Xiaoli Wang Saeed Arefanian Alexander Zheleznyak Beatriz M. Carreno Ryuji Higashikubo Andrew E. Gelman Daniel Kreisel Daved H. Fremont Alexander Sasha Krupnick Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy
description	High-affinity IL-2Rα expressed by Tregs mitigates the potential of IL-2 use in cancer therapy. Here, the authors fuse IL-2 with an NKDG2 binding domain, and show that it induces IL-2 signalling selectively in NKG2D+cells, delaying tumour growth in mice without the side effects of conventional IL-2 therapy.
format	article
author	Reza Ghasemi Eric Lazear Xiaoli Wang Saeed Arefanian Alexander Zheleznyak Beatriz M. Carreno Ryuji Higashikubo Andrew E. Gelman Daniel Kreisel Daved H. Fremont Alexander Sasha Krupnick
author_facet	Reza Ghasemi Eric Lazear Xiaoli Wang Saeed Arefanian Alexander Zheleznyak Beatriz M. Carreno Ryuji Higashikubo Andrew E. Gelman Daniel Kreisel Daved H. Fremont Alexander Sasha Krupnick
author_sort	Reza Ghasemi
title	Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy
title_short	Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy
title_full	Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy
title_fullStr	Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy
title_full_unstemmed	Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy
title_sort	selective targeting of il-2 to nkg2d bearing cells for improved immunotherapy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/556e5f18a8074910ad3823823e1bf265
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Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy

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