LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer

LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer

LRIG1 is a tumour suppressor in several cancers. Here, the authors show that androgen receptor directly transactivates LRIG1 which then antagonises ERBB signalling and c-Myc expression to inhibit prostate tumorigenesis.

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Bibliographic Details
Main Authors: Qiuhui Li, Bigang Liu, Hsueh-Ping Chao, Yibing Ji, Yue Lu, Rashid Mehmood, Collene Jeter, Taiping Chen, John R. Moore, Wenqian Li, Can Liu, Kiera Rycaj, Amanda Tracz, Jason Kirk, Tammy Calhoun-Davis, Jie Xiong, Qu Deng, Jiaoti Huang, Barbara A. Foster, Abhiram Gokhale, Xin Chen, Dean G. Tang
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/556fc4b133f24b85b14cddf5c742adf8
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https://doaj.org/article/556fc4b133f24b85b14cddf5c742adf8

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