LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer

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LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer

LRIG1 is a tumour suppressor in several cancers. Here, the authors show that androgen receptor directly transactivates LRIG1 which then antagonises ERBB signalling and c-Myc expression to inhibit prostate tumorigenesis.

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Detalles Bibliográficos
Autores principales:	Qiuhui Li, Bigang Liu, Hsueh-Ping Chao, Yibing Ji, Yue Lu, Rashid Mehmood, Collene Jeter, Taiping Chen, John R. Moore, Wenqian Li, Can Liu, Kiera Rycaj, Amanda Tracz, Jason Kirk, Tammy Calhoun-Davis, Jie Xiong, Qu Deng, Jiaoti Huang, Barbara A. Foster, Abhiram Gokhale, Xin Chen, Dean G. Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/556fc4b133f24b85b14cddf5c742adf8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Descripción
Sumario:	LRIG1 is a tumour suppressor in several cancers. Here, the authors show that androgen receptor directly transactivates LRIG1 which then antagonises ERBB signalling and c-Myc expression to inhibit prostate tumorigenesis.