LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer
LRIG1 is a tumour suppressor in several cancers. Here, the authors show that androgen receptor directly transactivates LRIG1 which then antagonises ERBB signalling and c-Myc expression to inhibit prostate tumorigenesis.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/556fc4b133f24b85b14cddf5c742adf8 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:556fc4b133f24b85b14cddf5c742adf8 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:556fc4b133f24b85b14cddf5c742adf82021-12-02T14:39:36ZLRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer10.1038/s41467-019-13532-42041-1723https://doaj.org/article/556fc4b133f24b85b14cddf5c742adf82019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13532-4https://doaj.org/toc/2041-1723LRIG1 is a tumour suppressor in several cancers. Here, the authors show that androgen receptor directly transactivates LRIG1 which then antagonises ERBB signalling and c-Myc expression to inhibit prostate tumorigenesis.Qiuhui LiBigang LiuHsueh-Ping ChaoYibing JiYue LuRashid MehmoodCollene JeterTaiping ChenJohn R. MooreWenqian LiCan LiuKiera RycajAmanda TraczJason KirkTammy Calhoun-DavisJie XiongQu DengJiaoti HuangBarbara A. FosterAbhiram GokhaleXin ChenDean G. TangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Qiuhui Li Bigang Liu Hsueh-Ping Chao Yibing Ji Yue Lu Rashid Mehmood Collene Jeter Taiping Chen John R. Moore Wenqian Li Can Liu Kiera Rycaj Amanda Tracz Jason Kirk Tammy Calhoun-Davis Jie Xiong Qu Deng Jiaoti Huang Barbara A. Foster Abhiram Gokhale Xin Chen Dean G. Tang LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer |
| description |
LRIG1 is a tumour suppressor in several cancers. Here, the authors show that androgen receptor directly transactivates LRIG1 which then antagonises ERBB signalling and c-Myc expression to inhibit prostate tumorigenesis. |
| format |
article |
| author |
Qiuhui Li Bigang Liu Hsueh-Ping Chao Yibing Ji Yue Lu Rashid Mehmood Collene Jeter Taiping Chen John R. Moore Wenqian Li Can Liu Kiera Rycaj Amanda Tracz Jason Kirk Tammy Calhoun-Davis Jie Xiong Qu Deng Jiaoti Huang Barbara A. Foster Abhiram Gokhale Xin Chen Dean G. Tang |
| author_facet |
Qiuhui Li Bigang Liu Hsueh-Ping Chao Yibing Ji Yue Lu Rashid Mehmood Collene Jeter Taiping Chen John R. Moore Wenqian Li Can Liu Kiera Rycaj Amanda Tracz Jason Kirk Tammy Calhoun-Davis Jie Xiong Qu Deng Jiaoti Huang Barbara A. Foster Abhiram Gokhale Xin Chen Dean G. Tang |
| author_sort |
Qiuhui Li |
| title |
LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer |
| title_short |
LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer |
| title_full |
LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer |
| title_fullStr |
LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer |
| title_full_unstemmed |
LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer |
| title_sort |
lrig1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/556fc4b133f24b85b14cddf5c742adf8 |
| work_keys_str_mv |
AT qiuhuili lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT bigangliu lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT hsuehpingchao lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT yibingji lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT yuelu lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT rashidmehmood lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT collenejeter lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT taipingchen lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT johnrmoore lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT wenqianli lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT canliu lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT kierarycaj lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT amandatracz lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT jasonkirk lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT tammycalhoundavis lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT jiexiong lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT qudeng lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT jiaotihuang lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT barbaraafoster lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT abhiramgokhale lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT xinchen lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer AT deangtang lrig1isapleiotropicandrogenreceptorregulatedfeedbacktumorsuppressorinprostatecancer |
| _version_ |
1718390531088711680 |