Epicardial adipose tissue thickness correlates with the presence and severity of angiographic coronary artery disease in stable patients with chest pain.

<h4>Objective</h4>Epicardial adipose tissue (EAT) is suggested to correlate with metabolic risk factors and to promote plaque development in the coronary arteries. We sought to determine whether EAT thickness was associated or not with the presence and extent of angiographic coronary art...

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Autores principales:	Fabien A Picard, Pascal Gueret, Jean-Pierre Laissy, Stéphane Champagne, Florence Leclercq, Didier Carrié, Jean-Michel Juliard, Patrick Henry, Ralph Niarra, Gilles Chatellier, Philippe Gabriel Steg
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5572752270784f00bc176b3bab074ec2
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spelling	oai:doaj.org-article:5572752270784f00bc176b3bab074ec22021-11-25T05:55:39ZEpicardial adipose tissue thickness correlates with the presence and severity of angiographic coronary artery disease in stable patients with chest pain.1932-620310.1371/journal.pone.0110005https://doaj.org/article/5572752270784f00bc176b3bab074ec22014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0110005https://doaj.org/toc/1932-6203<h4>Objective</h4>Epicardial adipose tissue (EAT) is suggested to correlate with metabolic risk factors and to promote plaque development in the coronary arteries. We sought to determine whether EAT thickness was associated or not with the presence and extent of angiographic coronary artery disease (CAD).<h4>Methods</h4>We measured epicardial fat thickness by computed tomography and assessed the presence and extent of CAD by coronary angiography in participants from the prospective EVASCAN study. The association of EAT thickness with cardiovascular risk factors, coronary artery calcification scoring and angiographic CAD was assessed using multivariate regression analysis.<h4>Results</h4>Of 970 patients (age 60.9 years, 71% male), 75% (n = 731) had CAD. Patients with angiographic CAD had thicker EAT on the left ventricle lateral wall when compared with patients without CAD (2.74±2.4 mm vs. 2.08±2.1 mm; p = 0.0001). The adjusted odds ratio (OR) for a patient with a LVLW EAT value ≥2.8 mm to have CAD was OR = 1.46 [1.03-2.08], p = 0.0326 after adjusting for risk factors. EAT also correlated with the number of diseased vessels (p = 0.0001 for trend). By receiver operating characteristic curve analysis, an EAT value ≥2.8 mm best predicted the presence of>50% diameter coronary artery stenosis, with a sensitivity and specificity of 46.1% and 66.5% respectively (AUC:0.58). Coronary artery calcium scoring had an AUC of 0.76.<h4>Conclusion</h4>Although left ventricle lateral wall EAT thickness correlated with the presence and extent of angiographic CAD, it has a low performance for the diagnosis of CAD.Fabien A PicardPascal GueretJean-Pierre LaissyStéphane ChampagneFlorence LeclercqDidier CarriéJean-Michel JuliardPatrick HenryRalph NiarraGilles ChatellierPhilippe Gabriel StegPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e110005 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fabien A Picard Pascal Gueret Jean-Pierre Laissy Stéphane Champagne Florence Leclercq Didier Carrié Jean-Michel Juliard Patrick Henry Ralph Niarra Gilles Chatellier Philippe Gabriel Steg Epicardial adipose tissue thickness correlates with the presence and severity of angiographic coronary artery disease in stable patients with chest pain.
description	<h4>Objective</h4>Epicardial adipose tissue (EAT) is suggested to correlate with metabolic risk factors and to promote plaque development in the coronary arteries. We sought to determine whether EAT thickness was associated or not with the presence and extent of angiographic coronary artery disease (CAD).<h4>Methods</h4>We measured epicardial fat thickness by computed tomography and assessed the presence and extent of CAD by coronary angiography in participants from the prospective EVASCAN study. The association of EAT thickness with cardiovascular risk factors, coronary artery calcification scoring and angiographic CAD was assessed using multivariate regression analysis.<h4>Results</h4>Of 970 patients (age 60.9 years, 71% male), 75% (n = 731) had CAD. Patients with angiographic CAD had thicker EAT on the left ventricle lateral wall when compared with patients without CAD (2.74±2.4 mm vs. 2.08±2.1 mm; p = 0.0001). The adjusted odds ratio (OR) for a patient with a LVLW EAT value ≥2.8 mm to have CAD was OR = 1.46 [1.03-2.08], p = 0.0326 after adjusting for risk factors. EAT also correlated with the number of diseased vessels (p = 0.0001 for trend). By receiver operating characteristic curve analysis, an EAT value ≥2.8 mm best predicted the presence of>50% diameter coronary artery stenosis, with a sensitivity and specificity of 46.1% and 66.5% respectively (AUC:0.58). Coronary artery calcium scoring had an AUC of 0.76.<h4>Conclusion</h4>Although left ventricle lateral wall EAT thickness correlated with the presence and extent of angiographic CAD, it has a low performance for the diagnosis of CAD.
format	article
author	Fabien A Picard Pascal Gueret Jean-Pierre Laissy Stéphane Champagne Florence Leclercq Didier Carrié Jean-Michel Juliard Patrick Henry Ralph Niarra Gilles Chatellier Philippe Gabriel Steg
author_facet	Fabien A Picard Pascal Gueret Jean-Pierre Laissy Stéphane Champagne Florence Leclercq Didier Carrié Jean-Michel Juliard Patrick Henry Ralph Niarra Gilles Chatellier Philippe Gabriel Steg
author_sort	Fabien A Picard
title	Epicardial adipose tissue thickness correlates with the presence and severity of angiographic coronary artery disease in stable patients with chest pain.
title_short	Epicardial adipose tissue thickness correlates with the presence and severity of angiographic coronary artery disease in stable patients with chest pain.
title_full	Epicardial adipose tissue thickness correlates with the presence and severity of angiographic coronary artery disease in stable patients with chest pain.
title_fullStr	Epicardial adipose tissue thickness correlates with the presence and severity of angiographic coronary artery disease in stable patients with chest pain.
title_full_unstemmed	Epicardial adipose tissue thickness correlates with the presence and severity of angiographic coronary artery disease in stable patients with chest pain.
title_sort	epicardial adipose tissue thickness correlates with the presence and severity of angiographic coronary artery disease in stable patients with chest pain.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/5572752270784f00bc176b3bab074ec2
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Epicardial adipose tissue thickness correlates with the presence and severity of angiographic coronary artery disease in stable patients with chest pain.

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