The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival

Precision medicine needs prognostic markers to select the patients that will benefit more from targeted therapy. Authors show here that high level of baseline T cell receptor diversity is an indicator of favourable prognosis in multiple cancer types, and monoclonal expansion of T-cells correlates wi...

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Autores principales:	Sara Valpione, Piyushkumar A. Mundra, Elena Galvani, Luca G. Campana, Paul Lorigan, Francesco De Rosa, Avinash Gupta, John Weightman, Sarah Mills, Nathalie Dhomen, Richard Marais
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5580ae6b92b14a67a7ff151b6081830b
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spelling	oai:doaj.org-article:5580ae6b92b14a67a7ff151b6081830b2021-12-02T16:10:47ZThe T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival10.1038/s41467-021-24343-x2041-1723https://doaj.org/article/5580ae6b92b14a67a7ff151b6081830b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24343-xhttps://doaj.org/toc/2041-1723Precision medicine needs prognostic markers to select the patients that will benefit more from targeted therapy. Authors show here that high level of baseline T cell receptor diversity is an indicator of favourable prognosis in multiple cancer types, and monoclonal expansion of T-cells correlates with good response to immune checkpoint blockade therapy in metastatic melanoma patients.Sara ValpionePiyushkumar A. MundraElena GalvaniLuca G. CampanaPaul LoriganFrancesco De RosaAvinash GuptaJohn WeightmanSarah MillsNathalie DhomenRichard MaraisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara Valpione Piyushkumar A. Mundra Elena Galvani Luca G. Campana Paul Lorigan Francesco De Rosa Avinash Gupta John Weightman Sarah Mills Nathalie Dhomen Richard Marais The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
description	Precision medicine needs prognostic markers to select the patients that will benefit more from targeted therapy. Authors show here that high level of baseline T cell receptor diversity is an indicator of favourable prognosis in multiple cancer types, and monoclonal expansion of T-cells correlates with good response to immune checkpoint blockade therapy in metastatic melanoma patients.
format	article
author	Sara Valpione Piyushkumar A. Mundra Elena Galvani Luca G. Campana Paul Lorigan Francesco De Rosa Avinash Gupta John Weightman Sarah Mills Nathalie Dhomen Richard Marais
author_facet	Sara Valpione Piyushkumar A. Mundra Elena Galvani Luca G. Campana Paul Lorigan Francesco De Rosa Avinash Gupta John Weightman Sarah Mills Nathalie Dhomen Richard Marais
author_sort	Sara Valpione
title	The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
title_short	The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
title_full	The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
title_fullStr	The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
title_full_unstemmed	The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
title_sort	t cell receptor repertoire of tumor infiltrating t cells is predictive and prognostic for cancer survival
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5580ae6b92b14a67a7ff151b6081830b
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The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival

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