Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations

Recent studies have suggested that long genes (>100 kb) are more likely to be misregulated in some neurological diseases, such as autism and Rett syndrome. Here the authors find that the apparent length-dependent trends previously observed in MeCP2 microarray and RNA-sequencing datasets disappear...

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Auteurs principaux: Ayush T. Raman, Amy E. Pohodich, Ying-Wooi Wan, Hari Krishna Yalamanchili, William E. Lowry, Huda Y. Zoghbi, Zhandong Liu
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/558d10a20c1240ebb849e9756a465fe5
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