Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations

Recent studies have suggested that long genes (>100 kb) are more likely to be misregulated in some neurological diseases, such as autism and Rett syndrome. Here the authors find that the apparent length-dependent trends previously observed in MeCP2 microarray and RNA-sequencing datasets disappear...

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Autores principales:	Ayush T. Raman, Amy E. Pohodich, Ying-Wooi Wan, Hari Krishna Yalamanchili, William E. Lowry, Huda Y. Zoghbi, Zhandong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/558d10a20c1240ebb849e9756a465fe5
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spelling	oai:doaj.org-article:558d10a20c1240ebb849e9756a465fe52021-12-02T17:32:15ZApparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations10.1038/s41467-018-05627-12041-1723https://doaj.org/article/558d10a20c1240ebb849e9756a465fe52018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05627-1https://doaj.org/toc/2041-1723Recent studies have suggested that long genes (>100 kb) are more likely to be misregulated in some neurological diseases, such as autism and Rett syndrome. Here the authors find that the apparent length-dependent trends previously observed in MeCP2 microarray and RNA-sequencing datasets disappeared after controlling for baseline variations.Ayush T. RamanAmy E. PohodichYing-Wooi WanHari Krishna YalamanchiliWilliam E. LowryHuda Y. ZoghbiZhandong LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ayush T. Raman Amy E. Pohodich Ying-Wooi Wan Hari Krishna Yalamanchili William E. Lowry Huda Y. Zoghbi Zhandong Liu Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations
description	Recent studies have suggested that long genes (>100 kb) are more likely to be misregulated in some neurological diseases, such as autism and Rett syndrome. Here the authors find that the apparent length-dependent trends previously observed in MeCP2 microarray and RNA-sequencing datasets disappeared after controlling for baseline variations.
format	article
author	Ayush T. Raman Amy E. Pohodich Ying-Wooi Wan Hari Krishna Yalamanchili William E. Lowry Huda Y. Zoghbi Zhandong Liu
author_facet	Ayush T. Raman Amy E. Pohodich Ying-Wooi Wan Hari Krishna Yalamanchili William E. Lowry Huda Y. Zoghbi Zhandong Liu
author_sort	Ayush T. Raman
title	Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations
title_short	Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations
title_full	Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations
title_fullStr	Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations
title_full_unstemmed	Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations
title_sort	apparent bias toward long gene misregulation in mecp2 syndromes disappears after controlling for baseline variations
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/558d10a20c1240ebb849e9756a465fe5
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Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations

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